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(hydroxocobalamin for injection)


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If cyanide poisoning is known or suspected, time may be running out.3

Comprehensive treatment of acute cyanide intoxication requires support of vital functions. Airway, ventilatory and circulatory support, oxygen administration, and management of seizures should not be delayed to administer CYANOKIT.3

The expert advice of a regional poison control center may be obtained by calling 1-800-222-1222.3

Treat with CYANOKIT—an FDA-approved treatment option for cyanide poisoning. Learn more about the signs and symptoms of cyanide poisoning and how CYANOKIT may help at

Product indication


CYANOKIT is indicated for the treatment of known or suspected cyanide poisoning.


Product Especification
To order or request a quote, call 1-800-638-8093
Key Product Specifications4:
NDC 11704-370-01
Delivers Full starting dose of 5 g of hydroxocobalamin in a single vial; diluent for infusion not included
Administration Type Intravenous infusion
Dimensions W: 194 mm x L: 100 mm x H: 97 mm
Packaged 1 kit per box
Kit Contains One 250-mL glass vial containing 5 g lyophilized hydroxocobalamin for injection; one sterile transfer spike; one sterile intravenous infusion set; one package insert; one quick-use reference guide
Storage: Lyophilized Form Store at 25°C (77°F); excursions permitted to 15°C-30°C (59°F-86°F) [See USP Controlled Room Temperature].

CYANOKIT may be exposed, during short periods, to temperature variations of usual transport, transport in the desert, and freezing/defrosting cycles.

  • Usual transport defined as 15 days subjected to temperatures ranging from 5°C-40°C (41°F-104°F)
  • Transport in the desert defined as 4 days subjected to temperatures ranging from 5°C-60°C (41°F-140°F)
  • Freezing/defrosting cycles defined as 15 days subjected to temperatures ranging from -20°F-40°C (-4°F-104°F)
Storage: Reconstituted Drug Product Once reconstituted, hydroxocobalamin is stable for up to 6 hours at temperatures not exceeding 40°C (104°F).
Do not freeze.
Any reconstituted product not used by 6 hours should be discarded.
Prescription Required Yes


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Product trademark
Download a product specifications PDF View full Prescribing Information for CYANOKIT® (hydroxocobalamin for injection) ORDER OR REQUEST A QUOTE Visit

CYANOKIT is a registered trademark of SERB Sarl, licensed by Meridian Medical Technologies, Inc., a Pfizer company.


<p><strong>CYANOKIT (hydroxocobalamin for injection)</strong></p> <p>In conjunction with CYANOKIT, treatment of cyanide poisoning must include immediate attention to airway patency, adequacy of oxygenation and hydration, cardiovascular support, and management of seizures. Consideration should be given to decontamination measures based on the route of exposure. Use caution in the management of patients with known anaphylactic reactions to hydroxocobalamin or cyanocobalamin. Consider alternative therapies, if available.</p> <p>Allergic reactions may include: anaphylaxis, chest tightness, edema, urticaria, pruritus, dyspnea, and rash. Allergic reactions including angioneurotic edema have also been reported in postmarketing experience.</p> <p>Cases of acute renal failure with acute tubular necrosis, renal impairment, and urine calcium oxalate crystals have been reported. In some situations, hemodialysis was required to achieve recovery. Regular monitoring of renal function, including but not limited to blood urea nitrogen (BUN) and serum creatinine, should be performed for 7 days following CYANOKIT therapy.</p> <p>Many patients with cyanide poisoning will be hypotensive; however, elevations in blood pressure have also been observed in known or suspected cyanide poisoning victims. Elevations in blood pressure (≥180 mmHg systolic or ≥110 mmHg diastolic) were observed in approximately 18% of healthy subjects (not exposed to cyanide) receiving hydroxocobalamin 5 g and 28% of subjects receiving 10 g. Increases in blood pressure were noted shortly after the infusions were started; the maximal increase in blood pressure was observed toward the end of the infusion. These elevations were generally transient and returned to baseline levels within 4 hours of dosing. Monitor blood pressure during treatment with CYANOKIT.</p> <p>Because of its deep red color, hydroxocobalamin has been found to interfere with colorimetric determination of certain laboratory parameters (e.g., clinical chemistry, hematology, coagulation, and urine parameters).</p> <p>Also because of its deep red color, hydroxocobalamin may cause hemodialysis machines to shut down due to an erroneous detection of a "blood leak." This should be considered before hemodialysis is initiated in patients treated with hydroxocobalamin.</p> <p>While it is not known if the skin redness predisposes to photosensitivity, patients should be advised to avoid direct sun while their skin remains discolored.</p> <p>Most common adverse reactions (&gt;5%) include transient chromaturia, erythema, oxalate crystals in urine, rash, increased blood pressure, nausea, headache, and infusion site reactions.</p> <p>Available data from cases reported in the published literature and postmarketing surveillance with CYANOKIT use in pregnant women are insufficient to identify a drug-associated risk for major birth defects, miscarriage, or adverse maternal and fetal outcomes. There are risks to the pregnant woman and fetus associated with untreated cyanide poisoning. In animal studies, hydroxocobalamin administered to pregnant rats and rabbits during the period of organogenesis caused skeletal and soft tissue abnormalities, including alterations in the central nervous system, at exposures similar to human exposures at the therapeutic dose.</p> <p>Breastfeeding is not recommended during treatment with CYANOKIT.</p>
<p class="title-indication"><strong>Indication<span class="colon">:</span></strong></p> <p>CYANOKIT is indicated for the treatment of known or suspected cyanide poisoning.</p> <p class="invisible-isi"><a class="isi-pdf-link" href="/sites/default/files/statement_on_serialization_requirements_exemption_.pdf" target="_blank">STATEMENT ON SERIALIZATION REQUIREMENTS EXEMPTION</a></p> <p class="indication-pi-link">Please see full <a href="/sites/default/files/cyanokit_uspi_2018.pdf" target="_blank">Prescribing Information</a>.</p>
Important Safety Information and Indication